Diabetes and Metabolic disorders
Our research on metabolic disorders is focused on glucose metabolic aberrations and dysfunctional cell signaling. The metabolic alterations are seen in highly prevalent diseases such as diabetes and rare diseases such as Lafora disease (LD). We are interested in deciphering the biochemical signaling and cellular alterations that form the mechanistic basis of metabolic disorders. We are specifically interested in hormonal signaling that regulates metabolism, protein modifications, and protein degradation. Our research aims to discover 'druggable' targets for the metabolic disorders
Cancer Pharmacology
Alterations in cellular metabolism are an emerging hallmark of cancer development. Warburg effect observed in various cancers is a testament to metabolic reprogramming by cancer cells. We are currently researching the interface between reprogrammed cancer metabolism and cancer biology such as epigenetic changes, cell cycle, cell death, and tumor microenvironment. We are interested in decoding novel targets in cellular metabolism that could help in our fight against deadly cancers such as glioblastoma and pancreatic cancer.
Our work is supported by: