RESEARCH PUBLICATIONS
24. The effect of hormones insulin and glucagon on ubiquitin modifications elucidated by proteomics in liver cells.
Hari Priya Vemana, Vikas V Dukhande
Life Sci. 2023 Sep 15;329:121935. doi: 10.1016/j.lfs.2023.121935. Epub 2023 Jul 12.
23. Repurposing an Antiepileptic Drug for the Treatment of Glioblastoma.
Anjali Yadav #, Ali Alnakhli # , Hari Priya Vemana, Shraddha Bhutkar, Aaron Muth, Vikas V Dukhande
Pharm Res 2022 Nov;39(11):2871-2883. doi: 10.1007/s11095-022-03399-4.
# co-first authors.
22. Metabolic Alterations and Mitochondrial Dysfunction Underlie Hepatocellular Carcinoma Cell Death Induced by a Glycogen Metabolic Inhibitor
Shrikant Barot, Olivia Stephenson , Hari Priya Vemana , Anjali Yadav , Shraddha Bhutkar , Louis Trombetta , Vikas V Dukhande
Biochem Pharmacology. 2022 Aug 1;115201. doi: 10.1016/j.bcp.2022.115201. Online ahead of print.
21. Galactose-decorated liver tumor-specific nanoliposomes incorporating selective BRD4-targeted PROTAC for hepatocellular carcinoma therapy.
Saraswat A, Vemana HP, Dukhande VV, Patel K.
Heliyon. 2022 Jan 3;8(1):e08702. doi: 10.1016/j.heliyon.2021.e08702. eCollection 2022 Jan.PMID: 35036599
20. A novel gene therapy for neurodegenerative Lafora disease via EPM2A-loaded DLinDMA lipoplexes.
Vemana HP, Saraswat A, Bhutkar S, Patel K, Dukhande VV.
Nanomedicine (Lond). 2021 Jun;16(13):1081-1095. doi: 10.2217/nnm-2020-0477. Epub 2021 May 7.PMID: 33960213
19. Development of Dual ARV-825 and Nintedanib-Loaded PEGylated Nano-Liposomes for Synergistic Efficacy in Vemurafnib-Resistant Melanoma.
Fu Y, Saraswat A, Wei Z, Agrawal MY, Dukhande VV, Reznik SE, Patel K.
Pharmaceutics. 2021 Jul 1;13(7):1005. doi: 10.3390/pharmaceutics13071005.
18. In vitro assessment of a synergistic combination of gemcitabine and zebularine in pancreatic cancer cells.
Patki M, Saraswat A, Bhutkar S, Dukhande V, Patel K.
Exp Cell Res. 2021 Aug 15;405(2):112660. doi: 10.1016/j.yexcr.2021.112660. Epub 2021 May 25.PMID: 34048785
17. Optimizing the aryl-triazole of cjoc42 for enhanced gankyrin binding and anti-cancer activity.
Kanabar D, Farrales P, Kabir A, Juang D, Gnanmony M, Almasri J, Torrents N, Shukla S, Gupta V, Dukhande VV, D'Souza A, Muth A.Bioorg Med Chem Lett. 2020 Sep 1;30(17):127372. doi: 10.1016/j.bmcl.2020.127372. Epub 2020 Jul 2.PMID: 32738965
16. Structural modification of the aryl sulfonate ester of cjoc42 for enhanced gankyrin binding and anti-cancer activity.
Kanabar D, Farrales P, Gnanamony M, Almasri J, Abo-Ali EM, Otmankel Y, Shah H, Nguyen D, El Menyewi M, Dukhande VV, D'Souza A, Muth A.Bioorg Med Chem Lett. 2020 Feb 15;30(4):126889. doi: 10.1016/j.bmcl.2019.126889. Epub 2019 Dec 16.PMID: 31902711
15. EphA2-Receptor Targeted PEGylated Nanoliposomes for the Treatment of BRAF V600E Mutated Parent- And Vemurafenib-Resistant Melanoma
Yige Fu, Drishti Rathod, Ehab M Abo-Ali, Vikas V Dukhande, Ketan Patel
Pharmaceutics, 11 (10), 2019 Oct 1
14. Nuclear Glycogenolysis Modulates Histone Acetylation in Human Non-Small Cell Lung Cancers.
Sun RC, Dukhande VV, Zhou Z, Young LEA, Emanuelle S, Brainson CF, Gentry MS.
Cell Metab. 2019 Aug 29. pii: S1550-4131(19)30443-7. doi: 10.1016/j.cmet.2019.08.014. [Epub ahead of print]
13. Inhibition of glycogen catabolism induces intrinsic apoptosis and augments multikinase inhibitors in hepatocellular carcinoma cells,
Experimental Cell Research, 2019, https://doi.org/10.1016/j.yexcr.2019.05.017
Shrikant Barot, Ehab M. Abo-Ali, Daisy L. Zhou, Christian Palaguachi, Vikas V. Dukhande
12. Structural mechanism of laforin function in glycogen dephosphorylation and Lafora disease.
Molecular Cell, December 2014, doi: 10.1016/j.molcel.2014.11.020
Raththagala M, Brewer MK, Parker M, Sherwood AR, Wong BK, Hsu S, Bridges TM, Paasch BC, Hellman LM, Husodo S, Meekins DA, Taylor AO, Turner BD, Auger KD, Dukhande VV, Chakravarthy S, Sanz P, Woods Jr. VV, Li S, Vander Kooi CW, Gentry MS.
11. HUWE1 is a molecular link controlling RAF-1 activity supported by the Shoc2 scaffold
Molecular and Cellular Biology, July 2014, doi:10.1128/MCB.00811-14
Jang ER, Shi P, Bryant J, Chen J, Dukhande VV, Gentry MS, Jang H, Jeoung M, and Galperin E.
10. Expression, purification and characterization of soluble red rooster laforin as a fusion protein in Escherichia coli.BMC Biochemistry. April 2014, doi: 10.1186/1471-2091-15-8
Brewer MK, Husodo S, Dukhande VV, Johnson MB, Gentry MS.
9. Neuroprotection against neuroblastoma cell death induced by depletion of mitochondrial glutathione.
Apoptosis. June 2013, doi: 10.1007/s10495-013-0836-4
Dukhande VV, Kawikova I, Bothwell ALM, Lai JC.
8. Laforin, a dual specificity phosphatase involved in Lafora disease, is present mainly as monomeric form with full phosphatase activity.
PLoS One. August 2011, doi: 10.1371/journal.pone.0024040
Dukhande VV, Rogers DM, Roma-Mateo C, Donderis J, Marina A, Taylor AO, Sanz P, Gentry MS.
7. Laforin, a dual specificity protein phosphatase involved in Lafora disease, is phosphorylated at Ser25 by AMP-activated protein kinase.
Biochemical Journal. October 2011, doi: 10.1042/BJ20110150
Romá-Mateo C, Solaz-Fuster MC, Gimeno-Alcañiz JV, Dukhande VV, Donderis J, Marina A, Criado O, Koller A, Cordoba SR, Gentry MS, Sanz P.
6. Chronic hypoxia-induced alterations of key enzymes of glucose oxidative metabolism in developing mouse liver are mTOR dependent.
Molecular Cellular Biochemistry. November 2011, doi: 10.1007/s11010-011-0889-z
Dukhande VV, Sharma G, Lai JCK, Farahani R.
5. Treatment of human astrocytoma U87 cells with silicon dioxide nanoparticles lowers their survival and alters their expression of mitochondrial and cell signaling proteins.
International Journal of Nanomedicine. October 2010, doi: 10.2147/IJN.S5238
Lai JC, Ananthakrishnan G, Jandhyam S, Dukhande VV, Bhushan A, Gokhale M, Daniels CK, Leung SW.
4. Reduced glutathione regenerating enzymes: sexual dimorphism and neurodevelopment in the rat brain cortex.
Brain Research. August 2009, doi: 10.1016/j.brainres.2009.05.029
Dukhande VV, Isaac AO, Chatterji T and Lai JCK.
3. Exposure to titanium dioxide and other metallic oxide nanoparticles induces cytotoxicity on human neural cells and fibroblasts.
International Journal of Nanomedicine. 2008, PMID: 19337421
Lai JC, Lai MB, Jandhyam S, Dukhande VV, Bhushan A, Daniels CK, Leung SW.
2. Metabolic and antioxidant system alterations in an astrocytoma cell line challenged with mitochondrial DNA deletion.
Neurochemical Research. November 2007, PMID: 17562167
Isaac AO, Dukhande VV, Lai JCK.
1. Manganese-induced neurotoxicity is differentially enhanced by glutathione depletion in astrocytoma and neuroblastoma cells.
Neurochemical Research. November 2006, PMID: 17053969
Dukhande VV, Malthankar-Phatak GH, Hugus JJ, Daniels CK and Lai JCK.
REVIEW AND BOOK CHAPTERS
4. Recent advances in the application of nanomedicine for the treatment of diabetes.
Vemana HP, Dukhande VV.
Nanomedicine (Lond). 2022 Jan;17(2):65-69. doi: 10.2217/nnm-2021-0338. Epub 2022 Jan 5.PMID: 34983192
3. Methods for Studying TNFα-Induced Autophagy.
Najafi S, Abo-Ali EM, Dukhande VV.
Methods Mol Biol. 2020;2108:131-146. doi: 10.1007/978-1-0716-0247-8_12.PMID: 31939177
2. Function and action of the glucan phosphatase laforin.
Sherwood AR, Dukhande VV, Gentry MS. Encyclopedia of Signaling Molecules. 2012
1. Laforin- Nature Molecule Page.
Dukhande VV, Sherwood A, Gentry MS. UCSD-Nature Molecule Pages. 2010